S100A8/A9 in bleomycin-induced skin fibrosis
نویسندگان
چکیده
منابع مشابه
Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats
Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human. Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...
متن کاملA Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats
Background: The purpose of this study was to compare the effects of saffron and methylprednisolone on bleomycin-induced pulmonary fibrosis in rats. Methods: This study was conducted in Bushehr, southern Iran in 2017.The animals were divided into four groups of five rats each. Three groups were injected with a single intratracheal dose of bleomycin (5 mg/kg). The fourth group was administered w...
متن کاملThe Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats
Background & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach used in IPF cases is the usage of chemical or herbal antioxidants in order to elim...
متن کاملCombined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis
INTRODUCTION Systemic sclerosis (SSc) is a connective tissue disorder characterised by the development of skin fibrosis. Our current understanding of the disease pathogenesis is incomplete and the study of SSc is hindered, at least partially, by a lack of animal models that fully replicate the complex state of human disease. Murine model of bleomycin-induced dermal fibrosis encapsulates importa...
متن کاملIL-12 attenuates bleomycin-induced pulmonary fibrosis.
Interleukin (IL)-12 is a potent inducer of interferon (IFN)-gamma. We postulated that IL-12 would attenuate bleomycin-induced pulmonary fibrosis. To test this hypothesis, we administered IL-12 or murine serum albumin to bleomycin-treated mice by daily intraperitoneal injection until day 12. Mice treated with IL-12 demonstrated decreased hydroxyproline levels compared with control treated mice. ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2011
ISSN: 0003-4967
DOI: 10.1136/ard.2010.149104.10